Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Co-activator candidate interactions for orphan nuclear receptor NR2E1.

BMC genomics - 26 Oct 2016

Corso-Díaz Ximena, de Leeuw Charles N, Alonso Vivian, Melchers Diana, Wong Bibiana K Y, Houtman René, Simpson Elizabeth M

Abstract excerpt

BACKGROUND: NR2E1 (Tlx) is an orphan nuclear receptor that regulates the maintenance and self-renewal of neural stem cells, and promotes tumourigenesis. Nr2e1-null mice exhibit reduced cortical and limbic structures and pronounced retinal dystrophy. NR2E1 functions mainly as a repressor of gene transcription in association with the co-repressors atrophin-1, LSD1, HDAC and BCL11A. Recent evidence suggests that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Drug Discovery
Share to Ligands

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Orphan Nuclear Receptors

Share to Protein Interaction Domains and Motifs

Share to Protein Interaction Mapping

Share to Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 27782803
DOI: 10.1186/s12864-016-3173-5
PMCID: PMC5080790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-activator candidate interactions for orphan nuclear receptor NR2E1.PMID 27782803Read ↗

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations.Semantic proximity Read ↗

Nuclear Receptor Coregulators and Human DiseaseSemantic proximity Read ↗

Characterization of the Nurr1 ligand-binding domain co-activator interaction surface.Semantic proximity Read ↗

TurboID proximity interactome mapping reveals NR2E3 association with AP-1 and retinal developmental complexesSemantic proximity Read ↗

The nuclear receptor subfamily 4 group A1 in human diseaseSemantic proximity Read ↗

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell BiologySemantic proximity Read ↗

Reversible control of T cell exhaustion by NR4A transcription factors revealed through targeted protein degradationSemantic proximity Read ↗

PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motifSemantic proximity Read ↗

JMJD2A Is a Novel N-CoR-Interacting Protein and Is Involved in Repression of the Human Transcription Factor Achaete Scute-Like Homologue 2 (ASCL2/Hash2)Semantic proximity Read ↗

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization.Semantic proximity Read ↗

A novel variant of NR5A1, p.R350W implicates potential interactions with unknown co-factors or ligands.Semantic proximity Read ↗

The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.