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Article

Maternal function of a retroviral-type zinc-finger protein is essential for Drosophila development.

Developmental genetics - 1 Jan 1999

McNeil G P, Zhang X, Roberts M, Jackson F R

Abstract excerpt

Previous studies have shown that zygotic expression of the Drosophila lark gene, which encodes an RNA-binding protein, is essential for embryogenesis. We now show that lark mRNA is abundant in preblastoderm (0-2 h) embryos, prior to zygotic transcription, indicative of maternal inheritance. Lark can also be detected within the nurse cells of developing egg chambers, suggesting a function for the protein during...

Topics

Animals
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Embryonic Development
Immunohistochemistry
In Situ Hybridization
Insect Proteins
Mutagenesis, Site-Directed
Oogenesis
Ovum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Messenger

RNA-Binding Proteins

Zinc Fingers

Source

Identifiers

PMID: 10570470
DOI: 10.1002/(SICI)1520-6408(1999)25:4<387::AID-DVG12>3.0.CO;2-P

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