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Article

A conserved maternal-specific repressive domain in Zelda revealed by Cas9-mediated mutagenesis in Drosophila melanogaster.

PLoS genetics - 1 Dec 2017

Hamm Danielle C, Larson Elizabeth D, Nevil Markus, Marshall Kelsey E, Bondra Eliana R, Harrison Melissa M

Abstract excerpt

In nearly all metazoans, the earliest stages of development are controlled by maternally deposited mRNAs and proteins. The zygotic genome becomes transcriptionally active hours after fertilization. Transcriptional activation during this maternal-to-zygotic transition (MZT) is tightly coordinated with the degradation of maternally provided mRNAs. In Drosophila melanogaster, the transcription factor Zelda plays an...

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Identifiers

PMID: 29261646
DOI: 10.1371/journal.pgen.1007120
PMCID: PMC5752043

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