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Article

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer Module

1 Dec 1999

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 10570062
DOI: 10.1124/mol.56.6.1329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer ModulePMID 10570062Read ↗

Regulation of<i>CYP3A</i>Gene Transcription by the Pregnane X ReceptorSemantic proximity Read ↗

Identification of a human nuclear receptor defines a new signaling pathway for <i>CYP</i> <i>3</i> A inductionSemantic proximity Read ↗

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytesSemantic proximity Read ↗

Genome-wide discovery of drug-dependent human liver regulatory elements.Semantic proximity Read ↗

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 SuperfamilySemantic proximity Read ↗

Transcriptional co-operativity between distant retinoic acid response elements in regulation of<i>Cyp26A1</i>inducibilitySemantic proximity Read ↗

The Nuclear Xenobiotic Receptor Pregnane X Receptor: Recent Insights and New ChallengesSemantic proximity Read ↗

Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators.Semantic proximity Read ↗

Pregnane X Receptor as the “Sensor and Effector” in Regulating EpigenomeSemantic proximity Read ↗

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.Semantic proximity Read ↗

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.Semantic proximity Read ↗

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during EvolutionSemantic proximity Read ↗

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