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A functional genomic analysis of type 3 <i>Streptococcus pneumoniae</i> virulence

1 May 2001

Abstract excerpt

Streptococcus pneumoniae remains a serious cause of morbidity and mortality in humans, but relatively little is known about the molecular basis of its pathogenesis. We used signature-tagged mutagenesis together with an analysis of S. pneumoniae genome sequence to identify and characterize genes required for pathogenesis. A library of signature-tagged mutants was created by insertion-duplication mutagenesis, and...

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PMID: 11359563
DOI: 10.1046/j.1365-2958.2001.02335.x

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