Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Novel Virulence Determinants inMycobacterium paratuberculosisby Screening a Library of Insertional Mutants

21 Jun 2006

Abstract excerpt

Johne's disease, caused by Mycobacterium paratuberculosis infection, is a worldwide problem for the dairy industry and has a possible involvement in Crohn's disease in humans. To identify virulence determinants of this economically important pathogen, a library of 5,060 transposon mutants was constructed using Tn5367 insertion mutagenesis, followed by large-scale sequencing to identify disrupted genes. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology
Share to Veterinary medicine and infectious diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16790754
DOI: 10.1128/iai.01742-05

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Novel Virulence Determinants inMycobacterium paratuberculosisby Screening a Library of Insertional MutantsPMID 16790754Read ↗

Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne’s DiseaseSemantic proximity Read ↗

Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence.Semantic proximity Read ↗

Construction and screening of Mycobacterium paratuberculosis insertional mutant libraries.Semantic proximity Read ↗

Generation and screening of a comprehensive Mycobacterium avium subsp. paratuberculosis transposon mutant bank.Semantic proximity Read ↗

Attenuated strains of Mycobacterium avium subspecies paratuberculosis as vaccine candidates against Johne's disease.Semantic proximity Read ↗

A transposon insertion mutant of Mycobacterium fortuitum attenuated in virulence and persistence in a murine infection model that is complemented by Rv3291c of Mycobacterium tuberculosis.Semantic proximity Read ↗

Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity Read ↗

High-density transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity Read ↗

Identification of Mycobacterium marinum macrophage infection mutants.Semantic proximity Read ↗

Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strainsSemantic proximity Read ↗

The Mycobacterium avium ssp. paratuberculosis specific mptD gene is required for maintenance of the metabolic homeostasis necessary for full virulence in mouse infections.Semantic proximity Read ↗

High-throughput functional genomics: A (myco)bacterial perspective.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.