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Article

Subcellular localization of Hairless protein shows a major focus of activity within the nucleus.

Mechanisms of development - 1 Dec 1999

Maier D, Nagel A C, Johannes B, Preiss A

Abstract excerpt

Hairless, a major antagonist of the Notch signaling-pathway in Drosophila (Bang and Posakony, 1992; Maier et al., 1992), associates with Suppressor of Hairless [Su(H)], thereby inhibiting trans-activation of Notch target genes (Brou et al., 1994). These molecular interactions could occur either at the step of signal transduction in the cytoplasm or during implementation of the signal within the nucleus. We...

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Identifiers

PMID: 10559498
DOI: 10.1016/s0925-4773(99)00208-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Subcellular localization of Hairless protein shows a major focus of activity within the nucleus.PMID 10559498Read ↗

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

[The mouse hairless gene: its function in hair root and at the heart of a subtle pleiotropy].Semantic proximity Read ↗

Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.Semantic proximity Read ↗

In vivo structure-function analysis of Drosophila Hairless.Semantic proximity Read ↗

Dissecting the mechanisms of suppressor of hairless function.Semantic proximity Read ↗

Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless.Semantic proximity Read ↗

Functional mapping of the mouse <i>hairless</i> gene promoter regionSemantic proximity Read ↗

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.Semantic proximity Read ↗

In vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila.Semantic proximity Read ↗

The "bald Mill Hill" mutation in the mouse is associated with an abnormal, mislocalized HR bmh protein.Semantic proximity Read ↗

Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.Semantic proximity Read ↗

Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.Semantic proximity Read ↗

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