Article
Malignant B-cell intra-clonal diversification: following the yarn in the labyrinth.
Leukemia & lymphoma - 1 Nov 2011
Nadav-Dagan Liat, Katz Ben-Zion
Abstract excerpt
The generation of cellular diversity is considered a key factor in the development of cancer. The research of B-cell malignancies provides a unique opportunity to study the origin, regulation, and physiological significance of diversification mechanisms, due to active alterations of the immunoglobulin genes in these cells. These genes provide a distinctive marker common to all of the malignant cells in a single...
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