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Article

Cellular origin and clonality of classic Hodgkin's lymphoma: immunophenotypic and molecular studies.

Seminars in hematology - 1 Jul 1999

Stein H, Hummel M

Abstract excerpt

The cellular origin of Hodgkin and Reed-Sternberg (HRS) cells, the neoplastic cells of classic Hodgkin's lymphoma (HL), resisted clarification until the second half of this decade. One major obstacle to successful experimental investigations was the rarity of the HRS cells in the tissue affected by HL. Immunophenotypical studies using monoclonal antibodies already pointed in the early 1980s towards a lymphocytic...

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PMID: 10462323

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