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Article

Lymphoma stem cells: enough evidence to support their existence?

1 Feb 2010

Abstract excerpt

While leukemia-originating stem cells are critical in the initiation and maintenance of leukemias, the existence of similar cell populations that may generate B-cell lymphoma upon mutation remains uncertain. Here we propose that committed lymphoid progenitor/precursor cells with an active V-D-J recombination program are the initiating cells of follicular lymphoma and mantle cell lymphoma when targeted by...

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PMID: 20139392
DOI: 10.3324/haematol.2009.013318

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