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Article

The origin of B-cell chronic lymphocytic leukemia.

Seminars in oncology - 1 Apr 2006

Ghia Paolo, Caligaris-Cappio Federico

Abstract excerpt

An immunobiologic approach has led to substantial changes in our current view of chronic lymphocytic leukemia (CLL). Several questions remain unsolved and the definition of the cell origin of CLL is still prominent. The presence of somatic mutations of IGHV genes indicates that, at least in a portion of cases, CLL cells had encountered an antigen during the natural history of the disease. Unmutated (UM) cases...

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Share to BCR gene
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 16616061
DOI: 10.1053/j.seminoncol.2006.01.009

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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