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Article

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.

Science (New York, N.Y.) - 12 Nov 1999

Bonni A, Brunet A, West A E, Datta S R, Takasu M A, Greenberg M E

Abstract excerpt

A mechanism by which the Ras-mitogen-activated protein kinase (MAPK) signaling pathway mediates growth factor-dependent cell survival was characterized. The MAPK-activated kinases, the Rsks, catalyzed the phosphorylation of the pro-apoptotic protein BAD at serine 112 both in vitro and in vivo. The Rsk-induced phosphorylation of BAD at serine 112 suppressed BAD-mediated apoptosis in neurons. Rsks also are known to...

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PMID: 10558990
DOI: 10.1126/science.286.5443.1358

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BAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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