The dual role of ERK signaling in the apoptosis of neurons

Abstract excerpt

The extracellular signal-regulated kinase (ERK) signaling pathway participates in various cell responses, such as proliferation, migration, differentiation and death. In neuronal apoptosis, the ERK pathway has been shown to have a dual role. Although the majority of studies have demonstrated the ERK pathway to have an anti-apoptotic role in neurons, pro-apoptosis induced by ERK signaling, has also been observed....

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