Article
Basic fibroblast growth factor inhibits radiation-induced apoptosis of HUVECs. II. The RAS/MAPK pathway and phosphorylation of BAD at serine 112.
Radiation research - 1 Jun 2004
Gu Qingyang, Wang Dewen, Wang Xiaodan, Peng Ruiyun, Liu Jie, Deng Hua, Wang Zhaohai, Jiang Tao
Abstract excerpt
Radiation-induced endothelial cell apoptosis is involved in the development of many radiation injuries, including radiation-induced skin ulcers. The proangiogenic growth factor basic fibroblast growth factor (bFGF, NUDT6) enhances endothelial cell survival. In the present study, we set up a model of apoptosis in which primary cultured human umbilical vein endothelial cells (HUVECs) were irradiated with (60)Co...
Topics
- Apoptosis
- Carrier Proteins
- Cell Survival
- Cells, Cultured
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Endothelium, Vascular
- Fibroblast Growth Factor 2
- Gamma Rays
- Humans
- Mitogen-Activated Protein Kinases
- Mutation