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Article

Reelin signals survival through Src-family kinases that inactivate BAD activity.

Journal of neurochemistry - 1 Oct 2007

Ohkubo Nobutaka, Vitek Michael P, Morishima Atsuyuki, Suzuki Yoji, Miki Tetsuro, Maeda Nobuji, Mitsuda Noriaki

Abstract excerpt

Reelin plays an important role in the migration of embryonic neurons, but its continuing presence suggests additional functions in the brain. We now report a novel function where reelin protects P19 embryonal cells from apoptosis during retinoic acid-induced neuronal differentiation. This increased survival is associated with reelin activation of the phosphatidyl-inositol-3-kinase (PI3 K)/Akt pathway. When PI3 K...

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Source

Identifiers

PMID: 17696989
DOI: 10.1111/j.1471-4159.2007.04804.x

Genes

BAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Reelin signals survival through Src-family kinases that inactivate BAD activity.PMID 17696989Read ↗

Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases.Semantic proximity Read ↗

Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1.Semantic proximity Read ↗

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.Semantic proximity Read ↗

PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases.Semantic proximity Read ↗

Down-regulation of the tumor suppressor gene retinoic acid receptor beta2 through the phosphoinositide 3-kinase/Akt signaling pathway.Semantic proximity Read ↗

Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells.Semantic proximity Read ↗

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.Semantic proximity Read ↗

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RORalpha, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing.Semantic proximity Read ↗

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