Article
Disproportional body growth in female estrogen receptor-alpha-inactivated mice.
Biochemical and biophysical research communications - 19 Nov 1999
Vidal O, Lindberg M, Sävendahl L, Lubahn D B, Ritzen E M, Gustafsson J A, Ohlsson C
Abstract excerpt
Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of ERalpha in the regulation of body growth and skeletal growth. Adult female mice with inactivated...
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