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Sex-specific regulation of body size and bone slenderness by the acid labile subunit

26 Mar 2010

Abstract excerpt

Insulin-like growth factor 1 (IGF-1) is a crucial mediator of body size and bone mass during growth and development. In serum, IGF-1 is stabilized by several IGF-1-binding proteins (IGFBPs) and the acid labile subunit (ALS). Previous research using ALS knockout (ALSKO) mice indicated a growth retardation phenotype, and clinical reports of humans have indicated short stature and low bone mineral density (BMD) in...

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PMID: 20499371
DOI: 10.1002/jbmr.94

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