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Article

RNA branching and debranching in the yeast retrovirus-like element Ty1.

Science (New York, N.Y.) - 9 Jan 2004

Cheng Zhi, Menees Thomas M

Abstract excerpt

Ty elements of Saccharomyces cerevisiae are long terminal repeat (LTR) retroelements related to retroviruses. Normal levels of Ty1 transposition require Dbr1p, a cellular enzyme that cleaves 2'-5' RNA bonds. We show that Ty1 RNAs lacking identifiable 5' ends accumulate in virus-like particles (VLPs) in dbr1 mutants. Debranching this RNA in vitro with Dbr1p creates an uncapped version of the normal Ty1 RNA 5' end....

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Identifiers

PMID: 14716018
DOI: 10.1126/science.1087023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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RNA branching and debranching in the yeast retrovirus-like element Ty1.PMID 14716018Read ↗

Saccharomyces cerevisiae RNA lariat debranching enzyme, Dbr1p, is required for completion of reverse transcription by the retrovirus-like element Ty1 and cleaves branched Ty1 RNAs.Semantic proximity Read ↗

The yeast retrotransposons Ty1 and Ty3 require the RNA Lariat debranching enzyme, Dbr1p, for efficient accumulation of reverse transcripts.Semantic proximity Read ↗

Relationship between RNA lariat debranching and Ty1 element retrotransposition.Semantic proximity Read ↗

Isolation and characterization of the gene encoding yeast debranching enzyme.Semantic proximity Read ↗

Plus-strand strong-stop DNA synthesis in retrotransposon Ty1.Semantic proximity Read ↗

5′ to 3′ mRNA Decay Factors Colocalize with Ty1 Gag and Human APOBEC3G and Promote Ty1 RetrotranspositionSemantic proximity Read ↗

Fidelity of retrotransposon replication.Semantic proximity Read ↗

A specific terminal structure is required for Ty1 transposition.Semantic proximity Read ↗

P-body components are required for Ty1 retrotransposition during assembly of retrotransposition-competent virus-like particles.Semantic proximity Read ↗

Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance.Semantic proximity Read ↗

Extended interactions between the primer tRNAi(Met) and genomic RNA of the yeast Ty1 retrotransposon.Semantic proximity Read ↗

A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity.Semantic proximity Read ↗

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