Article
double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs.
Development (Cambridge, England) - 1 Dec 1999
Zilian O, Frei E, Burke R, Brentrup D, Gutjahr T, Bryant P J, Noll M
Abstract excerpt
We have isolated the discs overgrown gene of Drosophila and shown that it encodes a homolog of the Casein kinase I(delta)/(epsilon) subfamily and is identical to the double-time gene. However, in contrast to the weak double-time alleles, which appear to affect only the circadian rhythm, discs overgrown alleles, including bona fide null alleles, show strong effects on cell survival and growth control in imaginal...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Body Patterning
- Casein Kinase 1 epsilon
- Casein Kinases
- Cell Division
- Cell Survival
- Chromosome Mapping
- Clone Cells
- Drosophila
- Drosophila Proteins
- Homozygote
- Humans