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Article

Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta.

The Journal of biological chemistry - 23 Apr 2004

Peleg-Shulman Tal, Roisman Laila C, Zupkovitz Gordin, Schreiber Gideon

Abstract excerpt

Prolonging the circulatory half-life of low mass protein drugs can be achieved either by administration of a pro-drug or through co-injection with a carrier protein that will slowly release the active protein. The rate of release is concentration and affinity dependent. The optimal relationship between these two in prolonging the half-life of a pro-drug is the focus of this work. Interferon (IFN) beta is one of...

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Source

Identifiers

PMID: 14960565
DOI: 10.1074/jbc.M400033200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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