Article
Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface
1 Nov 2019
Abstract excerpt
To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of pathogenesis. Because of a lack of direct structural data, these interfaces are poorly understood. We report the structural analysis of full-length STAT1 binding to an interferon antagonist of a human pathogenic virus. The interface revealed by transferred cross-saturation NMR is complex,...
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