Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping proton wires in proteins: carbonic anhydrase and GFP chromophore biosynthesis.

The journal of physical chemistry. A - 2 Jul 2009

Shinobu Ai, Agmon Noam

Abstract excerpt

We have developed an algorithm for mapping proton wires in proteins and applied it to the X-ray structures of human carbonic anhydrase II (CA-II), the green fluorescent protein (GFP), and some of their mutants. For both proteins, we find more extensive proton wires than typically reported. In CA-II the active site wire exits to the protein surface, and leads to Glu69 and Asp72, located on an electronegative patch...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Hydrogen Bonding
Share to Models, Chemical

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Folding

Share to Protons

Share to Solutions

Share to Static Electricity

Source

Identifiers

PMID: 19388648
DOI: 10.1021/jp8102047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping proton wires in proteins: carbonic anhydrase and GFP chromophore biosynthesis.PMID 19388648Read ↗

Proton pathways in green fluorescence protein.Semantic proximity Read ↗

Excited state proton transfer in strongly enhanced GFP (sGFP2).Semantic proximity Read ↗

Proton transfer pathways in the mutant His-64-Ala of human carbonic anhydrase II.Semantic proximity Read ↗

Water-based hydrogen-atom wires as mediators in long-range proton-coupled electron transfer in enzymes: a new twist on water reactivity.Semantic proximity Read ↗

A theoretical study on the detection of proton transfer pathways in some mutants of human carbonic anhydrase II.Semantic proximity Read ↗

Hydrogen Sulfide Ligation in Hemoglobin I of Lucina pectinata─A QM/MM and Local Mode Study.Semantic proximity Read ↗

Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures.Semantic proximity Read ↗

A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore.Semantic proximity Read ↗

Photophysics of EGFP (E222H) Mutant, with Comparisons to Model Chromophores: Excited State pK's, Progressions, Quenching and Exciton Interaction.Semantic proximity Read ↗

Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II.Semantic proximity Read ↗

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.Semantic proximity Read ↗

Proposal for a hydrogen bond network in the active site of the prototypic gamma-class carbonic anhydrase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.