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Article

Carbonic anhydrase amyloid fibrils composed of laterally associated protofilaments show reduced cytotoxicity.

Biochemical and biophysical research communications - 19 Feb 2022

Ryabova Natalya, Fakhranurova Liliia, Balobanov Vitaly, Marchenkov Victor, Glukhov Anatoly, Ilyina Nelly, Kochetov Alexey, Suvorina Mariya, Surin Alexey, Katina Natalya

Abstract excerpt

Cytotoxicity of amyloid fibrils has been shown to depend on their structure. However, specific features of toxic and non-toxic amyloids remain unclear. Here we focus on the relationship between structural characteristics of the fibrils and their cytotoxicity. Bovine carbonic anhydrase B (BCAB) serves as the object of this study because its amyloids reduce cell viability. Limited proteolysis and mass spectrometry...

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Identifiers

PMID: 35051782
DOI: 10.1016/j.bbrc.2022.01.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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