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Article

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus.

The Journal of clinical investigation - 1 Nov 1999

Hani E H, Stoffers D A, Chèvre J C, Durand E, Stanojevic V, Dina C, Habener J F, Froguel P

Abstract excerpt

Type 2 diabetes mellitus is a common disabling disease with onset in middle-aged individuals, caused by an imbalance between insulin production and action. Genetic studies point to major genetic components, but, with the exception of maturity-onset diabetes of the young (MODY), specific diabetes susceptibility genes remain to be identified. Recent studies showed that a dominant negative mutation in the insulin...

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Identifiers

PMID: 10545531
DOI: 10.1172/JCI7469
PMCID: PMC409821

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Source receipt: pubmed, retrieved 7 Sept 2026.

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