Article
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus.
The Journal of clinical investigation - 1 Nov 1999
Hani E H, Stoffers D A, Chèvre J C, Durand E, Stanojevic V, Dina C, Habener J F, Froguel P
Abstract excerpt
Type 2 diabetes mellitus is a common disabling disease with onset in middle-aged individuals, caused by an imbalance between insulin production and action. Genetic studies point to major genetic components, but, with the exception of maturity-onset diabetes of the young (MODY), specific diabetes susceptibility genes remain to be identified. Recent studies showed that a dominant negative mutation in the insulin...
Topics
- Blood Glucose
- Blotting, Western
- Chloramphenicol O-Acetyltransferase
- DNA Mutational Analysis
- Diabetes Mellitus, Type 2
- Female
- France
- Genetic Predisposition to Disease
- Genotype
- Homeodomain Proteins
- Humans
- Insulin
- Male