Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.

doi:10.1172/JCI2242

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Article

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.

The Journal of clinical investigation - 1 Jul 1998

Stoffers D A, Stanojevic V, Habener J F

Abstract excerpt

The homeodomain transcription factor insulin promoter factor-1 (IPF-1) is required for development of the pancreas and also mediates glucose-responsive stimulation of insulin gene transcription. Earlier we described a human subject with pancreatic agenesis attributable to homozygosity for a cytos...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
COS Cells
Diabetes Mellitus, Type 2
HeLa Cells
Homeodomain Proteins
Humans
Insulinoma
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Open Reading Frames

Protein Biosynthesis

Rabbits

Structure-Activity Relationship

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Identifiers

PMID: 9649577
DOI: 10.1172/JCI2242
PMCID: PMC509085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9649577-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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