Article
Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family.
The Journal of clinical endocrinology and metabolism - 1 Feb 2004
Cockburn Brian N, Bermano Giovanna, Boodram Laura-Lee G, Teelucksingh Surujpal, Tsuchiya Takafumi, Mahabir Deepak, Allan Andrew B, Stein Roland, Docherty Kevin, Bell Graeme I
Abstract excerpt
This study investigated the prevalence of insulin promoter factor-1(IPF-1) mutations in familial early-onset diabetes mellitus in Trinidad. We screened 264 unrelated subjects with type 2 diabetes diagnosed before 40 yr of age and a family history of diabetes for mutations in the minimal promoter and coding region of the IPF-1 gene (IPF1). This study population included 169 patients of East Indian descent...
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