Article
Identification of a single nucleotide insertion polymorphism in the upstream region of the insulin promoter factor-1 gene: an association study with diabetes mellitus.
Diabetologia - 1 May 1998
Yamada K, Yuan X, Ishiyama S, Ichikawa F, Kohno S, Shoji S, Hayashi H, Nonaka K
Abstract excerpt
Insulin promoter factor 1 (IPF1) is a key factor both for the regulation of insulin gene expression and for the development of the pancreas. In this study 88 patients with non-insulin-dependent diabetes mellitus (NIDDM) who were diagnosed as diabetic at less than 40 years of age, 55 patients with...
Topics
- Adolescent
- Adult
- Alleles
- Base Sequence
- C-Peptide
- Child
- DNA Mutational Analysis
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Genes
- Genotype
- Guanine Nucleotides
- Heterozygote
- Homeodomain Proteins
- Homozygote
- Humans