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Article

Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans.

BMC medical genetics - 17 Oct 2005

Karim Mohammad A, Wang Xiaoqin, Hale Terri C, Elbein Steven C

Abstract excerpt

BACKGROUND: Defective insulin secretion is a key defect in the pathogenesis of type 2 diabetes (T2DM). The beta-cell specific transcription factor, insulin promoter factor 1 gene (IPF1), is essential to pancreatic development and the maintenance of beta-cell mass. We hypothesized that regulatory or coding variants in IPF1 contribute to defective insulin secretion and thus T2DM. METHODS: We screened 71 Caucasian...

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Identifiers

PMID: 16229747
DOI: 10.1186/1471-2350-6-37
PMCID: PMC1274317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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