Article
Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).
Diabetes - 1 Nov 2000
Clocquet A R, Egan J M, Stoffers D A, Muller D C, Wideman L, Chin G A, Clarke W L, Hanks J B, Habener J F, Elahi D
Abstract excerpt
Diabetes resulting from heterozygosity for an inactivating mutation of the homeodomain transcription factor insulin promoter factor 1 (IPF-1) is due to a genetic defect of beta-cell function referred to as maturity-onset diabetes of the young 4. IPF-1 is required for the development of the pancreas and mediates glucose-responsive stimulation of insulin gene transcription. To quantitate islet cell responses in a...
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