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IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes.

Metabolism: clinical and experimental - 1 Aug 2005

Gragnoli Claudia, Stanojevic Violeta, Gorini Antonio, Von Preussenthal Guido Menzinger, Thomas Melissa K, Habener Joel F

Abstract excerpt

Maturity-onset diabetes of the young (MODY) is a monogenic autosomal-dominant form of diabetes mellitus with onset before 25 years of age. Genetic variation in insulin promoter factor-1 (IPF1) (MODY4) is uncommon but may contribute to early- or late-onset diabetes as part of a polygenic background. IPF1 is a homeodomain transcription factor required for pancreas development. Our aim was to identify whether IPF1...

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PMID: 16092045
DOI: 10.1016/j.metabol.2005.01.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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