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Article

MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation.

Cell - 23 Jan 1998

Lieb J D, Albrecht M R, Chuang P T, Meyer B J

Abstract excerpt

We show that a functional component of the C. elegans mitotic machinery regulates X chromosome gene expression. This protein, MIX-1, is a member of the dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene expression during interphase. MIX-1 also associates with all mitotic chromosomes to ensure their proper segregation. Both dosage compensation and mitosis...

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PMID: 9458050
DOI: 10.1016/s0092-8674(00)80920-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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