Article
A novel gene, spp91-1, suppresses the splicing defect and the pre-mRNA nuclear export in the prp9-1 mutant.
The EMBO journal - 1 Sept 1992
Chapon C, Legrain P
Abstract excerpt
Processing and export of nuclear pre-mRNA are believed to be competing processes in the nucleus. In order to identify factors which are involved in these processes, we isolated suppressors that relieve the growth defect of a prp9-1 temperature-sensitive mutant strain of Saccharomyces cerevisiae. The prp9-1 mutation was previously shown to abolish splicing and to target pre-mRNA to the cytoplasm. One of the...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- Cell Nucleus
- Cloning, Molecular
- DNA Mutational Analysis
- DNA, Fungal
- Genes, Fungal
- Models, Genetic
- Molecular Sequence Data