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Article

Genealogical evidence for positive selection in the nef gene of HIV-1.

Genetics - 1 Nov 1999

Zanotto P M, Kallas E G, de Souza R F, Holmes E C

Abstract excerpt

The pattern and process of evolution in the nef gene of HIV-1 was analyzed within and among patients. Using a maximum likelihood method that allows for variable intensity of selection pressure among codons, strong positive selection was detected in a hemophiliac patient over 30 mo of infection. By reconstructing the process of allele substitution in this patient using parsimony, the synapomorphic amino acid...

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Identifiers

PMID: 10545443
DOI: 10.1093/genetics/153.3.1077
PMCID: PMC1460812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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