Article
Embryonic mesodermal defects in alpha 5 integrin-deficient mice.
Development (Cambridge, England) - 1 Dec 1993
Yang J T, Rayburn H, Hynes R O
Abstract excerpt
A loss of function mutation of the murine alpha 5 integrin gene generated by gene targeting in embryonic stem cells is a recessive embryonic lethal. The mutant embryos start to show observable defects by day 9 of gestation and die around day 10-11. The alpha 5-null embryos have pronounced defects...
Topics
- Animals
- Fibronectins
- Fluorescent Antibody Technique
- Gene Deletion
- Genotype
- Integrins
- Mesoderm
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Mutation
- Polymerase Chain Reaction
- Receptors, Fibronectin
- Stem Cells