Article
Embryonic mesodermal defects in alpha 5 integrin-deficient mice.
Development (Cambridge, England) - 1 Dec 1993
Yang J T, Rayburn H, Hynes R O
Abstract excerpt
A loss of function mutation of the murine alpha 5 integrin gene generated by gene targeting in embryonic stem cells is a recessive embryonic lethal. The mutant embryos start to show observable defects by day 9 of gestation and die around day 10-11. The alpha 5-null embryos have pronounced defects in posterior trunk and yolk sac mesodermal structures, suggesting a role for alpha 5 beta 1 integrin in mesoderm...
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