Article
Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
Molecular biology of the cell - 1 Sept 1998
Gardner R, Cronin S, Leader B, Rine J, Hampton R, Leder B
Abstract excerpt
The degradation rate of 3-hydroxy-3-methylglutaryl CoA reductase (HMG-R), a key enzyme of the mevalonate pathway, is regulated through a feedback mechanism by the mevalonate pathway. To discover the intrinsic determinants involved in the regulated degradation of the yeast HMG-R isozyme Hmg2p, we...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Binding Sites
- Endoplasmic Reticulum
- Hydroxymethylglutaryl CoA Reductases
- Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent
- Intracellular Membranes
- Membrane Proteins
- Molecular Sequence Data
- Phenotype