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Article

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene.

The EMBO journal - 1 Nov 1999

Harada N, Tamai Y, Ishikawa T, Sauer B, Takaku K, Oshima M, Taketo M M

Abstract excerpt

Ectopic expression of certain Wnt genes in mouse mammary tissue is tumorigenic, and mutations that stabilize beta-catenin are found in various human cancers including colorectal cancer. To determine the role of stabilized beta-catenin in intestinal tumorigenesis in mice, we constructed by embryonic stem (ES) cell-mediated homologous recombination, a mutant beta-catenin allele whose exon 3 was sandwiched by loxP...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10545105
DOI: 10.1093/emboj/18.21.5931
PMCID: PMC1171659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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