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Article

Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450.

Antimicrobial agents and chemotherapy - 1 May 1999

Asai K, Tsuchimori N, Okonogi K, Perfect J R, Gotoh O, Yoshida Y

Abstract excerpt

The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136 CYP51 gene in comparison with a reported CYP51 sequence from a wild-type, fluconazole-susceptible C. albicans...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10223930
DOI: 10.1128/AAC.43.5.1163
PMCID: PMC89127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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