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Article

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

17 Jan 2006

Abstract excerpt

The target enzyme for fluconazole is sterol 14 alpha-demethylase, a cytochrome P450 encoded by cyp51. One mechanism of fluconazole resistance likely to occur in Candida albicans is through an altered target site. To test this hypothesis DNA sequencing of the cyp51 coding sequence from 19 fluconazole-resistant and 19 fluconazole-sensitive C. albicans was undertaken. A number of point mutations were identified in...

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PMID: 9228762
DOI: 10.1111/j.1574-6968.1997.tb12580.x

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