Article
Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients.
Antimicrobial agents and chemotherapy - 1 Oct 2001
Perea S, López-Ribot J L, Kirkpatrick W R, McAtee R K, Santillán R A, Martínez M, Calabrese D, Sanglard D, Patterson T F
Abstract excerpt
Molecular mechanisms of azole resistance in Candida albicans, including alterations in the target enzyme and increased efflux of drug, have been described, but the epidemiology of the resistance mechanisms has not been established. We have investigated the molecular mechanisms of resistance to azoles in C. albicans strains displaying high-level fluconazole resistance (MICs, > or =64 microg/ml) isolated from human...
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