Article

Most azole antifungal resistance mutations in the drug target provide cross-resistance and carry no intrinsic fitness cost

2023-12-14

Abstract excerpt

Azole antifungals are among the most frequently used drugs to treat fungal infections. Amino acid substitutions in and around the binding site of the azole target Erg11 (Cyp51) are a common resistance mechanism in pathogenic yeasts such as Candida albicans . How many and which mutations confer resistance, and at what cost, is however largely unknown. Here, we measure the impact of nearly 4,000 amino acid variants...

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Literature Corpus work: 89d98c96-e24e-53ac-abe0-98f2a935a14f
DOI: 10.1101/2023.12.13.571438

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