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Article

Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene.

Chinese medical journal - 5 Mar 2010

Feng Li-juan, Wan Zhe, Wang Xiao-hong, Li Ruo-yu, Liu Wei

Abstract excerpt

BACKGROUND: The cytochrome P450 lanosterol 14alpha-demethylase (Erg11p) encoded by ERG11 gene is the primary target for azole antifungals. Changes in azole affinity of this enzyme caused by amino acid substitutions have been reported as a mechanism of azole antifungal resistance. This study aimed to investigate the relationship between amino acid substitutions in Erg11p from fluconazole resistant Candida albicans...

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Share to Antifungal Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20367978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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