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Article

<i>Erg11</i>mutations associated with azole resistance in clinical isolates of<i>Candida albicans</i>

13 Mar 2013

Abstract excerpt

The widespread use of azoles has led to increasing azole resistance among Candida albicans strains. One mechanism of azole resistance involves point mutations in the ERG11 gene, which encodes the target enzyme (cytochrome P450 lanosterol 14α-demethylase). In the present study, we amplified and sequenced the ERG11 gene of 23 C. albicans clinical isolates. Seventeen mutations encoding distinct amino acid...

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PMID: 23480635
DOI: 10.1111/1567-1364.12042

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