Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selecting animal models of human aging: inbred strains often exhibit less biological uniformity than F1 hybrids.

Journal of gerontology - 1 Jan 1994

Phelan J P, Austad S N

Abstract excerpt

Most gerontological research is conducted using inbred strains of animals in an attempt to maximize phenotypic uniformity within experiments and thus increase the experimenter's statistical power to detect treatment effects. However, for a wide range of phenotypic traits, F1 hybrids between inbred strains are considerably less variable than the parental inbred strains themselves. Therefore, the use of F1 hybrids...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Chickens
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Biological

Share to Phenotype

Share to Plants

Source

Identifiers

PMID: 8282970
DOI: 10.1093/geronj/49.1.b1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selecting animal models of human aging: inbred strains often exhibit less biological uniformity than F1 hybrids.PMID 8282970Read ↗

Issues in the choice of genetic configuration for animal aging models.Semantic proximity Read ↗

Exotic mice as models for aging research: polemic and prospectus by R. Miller et al.Semantic proximity Read ↗

Pathobiology of aging rodents: inbred and hybrid models.Semantic proximity Read ↗

Genetic variability and rodent models of human aging.Semantic proximity Read ↗

Genes as gerontological variables: uniform genotypes.Semantic proximity Read ↗

Heterogeneous stocks and selective breeding in aging research.Semantic proximity Read ↗

Exotic mice as models for aging research: polemic and prospectus.Semantic proximity Read ↗

FRAR course on laboratory approaches to aging. Mouse and rat genotype choices.Semantic proximity Read ↗

Mouse and rat genotype choices.Semantic proximity Read ↗

A Genetically Heterogeneous Rat Model with Divergent Mitochondrial GenomesSemantic proximity Read ↗

Inbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies.Semantic proximity Read ↗

Genetic regulation of fasting-induced longevity effectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.