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Article

Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 1999

Emoto K, Kuge O, Nishijima M, Umeda M

Abstract excerpt

A CHO-K1 cell mutant with a specific decrease in cellular phosphatidylethanolamine (PE) level was isolated as a variant resistant to Ro09-0198, a PE-directed antibiotic peptide. The mutant was defective in the phosphatidylserine (PS) decarboxylation pathway for PE formation, in which PS produced in the endoplasmic reticulum is transported to mitochondria and then decarboxylated by an inner mitochondrial membrane...

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Identifiers

PMID: 10535934
DOI: 10.1073/pnas.96.22.12400
PMCID: PMC22930

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