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Article

Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells.

The Journal of cell biology - 22 Feb 1999

Fukasawa M, Nishijima M, Hanada K

Abstract excerpt

LY-A strain is a Chinese hamster ovary cell mutant resistant to sphingomyelin (SM)-directed cytolysin and has a defect in de novo SM synthesis. Metabolic labeling experiments with radioactive serine, sphingosine, and choline showed that LY-A cells were defective in synthesis of SM from these precursors, but not syntheses of ceramide (Cer), glycosphingolipids, or phosphatidylcholine, indicating a specific defect...

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Identifiers

PMID: 10037789
DOI: 10.1083/jcb.144.4.673
PMCID: PMC2132924

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