Article
Isolation of a chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells.
The Journal of biological chemistry - 15 Jan 1999
Kawasaki K, Kuge O, Chang S C, Heacock P N, Rho M, Suzuki K, Nishijima M, Dowhan W
Abstract excerpt
Phosphatidylglycerophosphate (PGP) synthase catalyzes the first step in the cardiolipin (CL) branch of phospholipid biosynthesis in mammalian cells. In this study, we isolated a Chinese hamster ovary (CHO) cDNA encoding a putative protein similar in sequence to the yeast PGS1 gene product, PGP sy...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cardiolipins
- Cricetinae
- DNA, Complementary
- Humans
- Microscopy, Electron
- Mitochondria
- Molecular Sequence Data
- Mutation
- Oxidative Phosphorylation
- Phosphatidylglycerols