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Article

Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.

The Journal of biological chemistry - 2 Dec 2005

Steenbergen Rineke, Nanowski Terry S, Beigneux Anne, Kulinski Agnes, Young Stephen G, Vance Jean E

Abstract excerpt

Most of the phosphatidylethanolamine (PE) in mammalian cells is synthesized by two pathways, the CDP-ethanolamine pathway and the phosphatidylserine (PS) decarboxylation pathway, the final steps of which operate at spatially distinct sites, the endoplasmic reticulum and mitochondria, respectively. We investigated the importance of the mitochondrial pathway for PE synthesis in mice by generating mice lacking PS...

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Identifiers

PMID: 16192276
DOI: 10.1074/jbc.M506510200
PMCID: PMC2888304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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