Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells.

Journal of inorganic biochemistry - 1 Oct 2004

Liang Xing-Jie, Shen Ding-Wu, Gottesman Michael M

Abstract excerpt

The resistance of tumors to cisplatin remains a major cause of treatment failure in cancer patients. Multiple, simultaneous alterations are frequently encountered in cancer cells selected for cisplatin resistance. To determine whether the complex phenotype results from many different cellular alterations, single-step variants were isolated based on one-step selection in cisplatin. Reduced drug accumulation is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboplatin
Share to Cell Membrane
Share to Cisplatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Endocytosis

Share to Lysosomes

Share to Methotrexate

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 15458822
DOI: 10.1016/j.jinorgbio.2004.05.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells.PMID 15458822Read ↗

Impaired cisplatin influx in an A2780 mutant cell line: Evidence for a putative, cis-configuration-specific, platinum influx transporterSemantic proximity Read ↗

A Chinese hamster ovary cell mutant defective in the non-endocytic uptake of fluorescent analogs of phosphatidylserine: isolation using a cytosol acidification protocol.Semantic proximity Read ↗

Disruption of Golgi morphology and trafficking in cells expressing mutant prenylated rab acceptor-1.Semantic proximity Read ↗

Isolation of a temperature-sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment.Semantic proximity Read ↗

Human hepatoma cell mutant defective in cell surface protein trafficking.Semantic proximity Read ↗

Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine.Semantic proximity Read ↗

Subcellular Localization and Activity of Multidrug Resistance ProteinsSemantic proximity Read ↗

Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell LineSemantic proximity Read ↗

Cancer Drug Resistance: Targeting Proliferation or Programmed Cell DeathSemantic proximity Read ↗

GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation.Semantic proximity Read ↗

Derivation and study of human epithelial cell lines resistant to killing by chromium trioxide.Semantic proximity Read ↗

Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.