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Article

Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 1999

Gangal M, Clifford T, Deich J, Cheng X, Taylor S S, Johnson D A

Abstract excerpt

Although the catalytic (C) subunit of cAMP-dependent protein kinase is N-myristylated, it is a soluble protein, and no physiological role has been identified for its myristyl moiety. To determine whether the interaction of the two regulatory (R) subunit isoforms (R(I) and R(II)) with the N-myristylated C subunit affects its ability to target membranes, the effect of N-myristylation and the R(I) and R(II) subunit...

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Identifiers

PMID: 10535933
DOI: 10.1073/pnas.96.22.12394
PMCID: PMC22929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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