Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus.

PLoS biology - 28 Oct 2008

Kuo Mario Meng-Chiang, Maslennikov Innokentiy, Molden Brent, Choe Senyon

Abstract excerpt

The RCK-containing MthK channel undergoes two inactivation processes: activation-coupled desensitization and acid-induced inactivation. The acid inactivation is mediated by the C-terminal RCK domain assembly. Here, we report that the desensitization gating is governed by a desensitization domain (DD) of the cytoplasmic N-terminal 17 residues. Deletion of DD completely removes the desensitization, and the process...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Archaeal Proteins
Share to Chromatography, Gel
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophysiology

Share to Hydrogen-Ion Concentration

Share to Hydrophobic and Hydrophilic Interactions

Share to Magnetic Resonance Spectroscopy

Share to Potassium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 18959476
DOI: 10.1371/journal.pbio.0060223
PMCID: PMC2573919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus.PMID 18959476Read ↗

The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.Semantic proximity Read ↗

Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.Semantic proximity Read ↗

Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands.Semantic proximity Read ↗

Mutation of a conserved Gln residue does not abolish desensitization of acid-sensing ion channel 1Semantic proximity Read ↗

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.Semantic proximity Read ↗

Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditionsSemantic proximity Read ↗

A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents.Semantic proximity Read ↗

Deep mutational scan of the pore of the cold-sensing TRPM8 channelSemantic proximity Read ↗

A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.Semantic proximity Read ↗

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.Semantic proximity Read ↗

A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels.Semantic proximity Read ↗

C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.